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Pellman Lab - Cell Division and Genome Instability

Pellman Lab - Cell Division and Genome Instability

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Shangming Tang
Shangming_Tang@dfci.harvard.edu 

EDUCATION
Research Fellow, UC Davis, Davis, California, USA

PhD, UC Davis, Davis, California, USA

MS, Peking University Health Science Center. Beijing, China

BS, Guangzhou Medical College, Guangzhou, China

​AWARDS AND HONORS
NIHS T32 Award (2012-2014)

SELECTED PUBLICATIONS
Tang S., Stokasimov E., Cui Y., Pellman D. (2022) Breakage of cytoplasmic chromosomes by pathological DNA base excision repair. Nature. (in press)

Tang S., Wu K.Y.M., Zhang R. Hunter N. (2015). Pervasive and essential roles of the Top3-Rmi1 decatenase orchestrate recombination and facilitate chromosome segregation in meiosis. Molecular Cell 57, 607-21.

Copsey, A., Tang, S*. Jordan, P., Blitzblau, H., Newcombe, S., Lambacher, N. Chan, A.C., Newnham, L., Li, Z., Arumugam, P., Hochwagen, A., Neil Hunter, N., Hoffmann, E. (2013). Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genetics 9, e1004071, doi:10.1371/journal.pgen.1004071.

Zakharyevich, K., Tang, S., Ma, Y., and Hunter, N. (2012). Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase. Cell 149, 334-347.

​Zakharyevich K, Ma Y, Tang S, Hwang PY, Boiteux S, Hunter N. (2010). Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions. Mol Cell 40, 1001-15.​

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