Our laboratory studies cell division, cell division and chromosome segregation errors in cancer, and the impact of these errors on cancer genome structure. We use genetics, biochemistry and live-cell imaging. We developed a method to combine long-term live-cell imaging with single cell isolation and single cell genomics (Look-Seq). Look-Seq enables morphological phenotype to be directly related to a cell’s genotype. With these approaches we recreate and dissect catastrophic mutational processes, common in cancer, that drive rapid genome evolution.